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MedFil is an industrial research project approved on the “Call for strategic industrial research projects aimed at the priority areas of the smart specialization strategy” (DGR 986/2018) within the POR-FESR EMILIA ROMAGNA 2014-2020, Axis 1 – Research and innovation, Action 1.2.2


CNR ISTEC – Leading partner
MISTER – Industrial research laboratory
Future research consortium – Industrial research laboratory
Romagna Tech – Center for innovation


  • Medica Spa
  • Pollution Srl
  • Fin-Ceramica Faenza Spa


HME devices, increasingly used for short-term use in anesthesia and in intensive long-term care units, accumulate heat and moisture from the patient’s exhaled breath, returning them during the inspiration phase. The humidity and temperature control of medical gases is essential to prevent damage to the patients’ tracheobronchial system. CNR-ISTEC has designed a new generation of HMEf devices, inspired by the natural composition of our respiratory system, totally biodegradable and produced by waste from the food chain. These filters are also used to reduce the transmission of potential pathogens and particulates to and from the breathing apparatus. The HMEf currently TRL4 are the subject of an international patent application. From the validations carried out according to ISO-9360-1 and ISO 9360-2, the devices have shown high performance in the exchange of heat and humidity and do not retain anesthetic drugs, in compliance with European standards.


The MEDFil goal is to design and functionalize a device for the protection of the respiratory tract, a process that will be secured through the administration of a wet and hot technical gas, and the early detection of microbial agents, a possible cause of respiratory tract infections. The project involves the validation of HMEDf devices (Heat and Moisture Exchange Diagnostic Filter) and the achievement of TRL6, together with: a) implementation of functionalized liposomal vesicles for microbial detection; b) integration with active modules (adsorbents / microfilters) based on polymeric membranes for the development of innovative multi-stage filtration systems, based on biocompatible and eco-sustainable materials developed and already patented within the consortium.